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New Pathway to Potential Therapies for Advanced Prostate Cancer

Dr. Nima Sharifi
Dr. Nima Sharifi

PSA Rising /DALLAS/ – July 25, 2011 – UT Southwestern Medical Center researchers have narrowed the potential drug targets for advanced prostate cancer by demonstrating that late-stage tumors are driven by a different hormonal pathway than previously was thought.

“We have recently discovered that castration resistant prostate cancer (CRPC) is unexpectedly driven by dihydrotestosterone synthesis from adrenal precursors in a pathway that circumvents testosterone,” says Dr. Nima Sharifi, assistant professor of internal medicine and senior author of a  study in Proceedings of the National Academy of Sciences.

“The dominant pathway to DHT synthesis from adrenal precursors in CRPC [castration resistant prostate cancer] follows an alternative route that bypasses T and requires steroid 5α-reductase isoenzyme-1 (SRD5A1),” Dr. Sharifi writes.
Continue reading New Pathway to Potential Therapies for Advanced Prostate Cancer

Provenge Trial Ongoing & Recruiting At Eight US Centers

An open-label study of Sipuleucel-T (Provenge) is ongoing at 8 centers across the USA. This is a Phase 2 Study enrolling men with Metastatic Castrate Resistant Prostate Cancer (CRPC).

The aim of this study is to measure the immune responses to treatment with sipuleucel-T (Provenge). All participants will receive the drug. Continue reading Provenge Trial Ongoing & Recruiting At Eight US Centers

Rick Ward: Pioneer Prostate Cancer Activist

Rick Ward, Prostate Cancer Awareness advocate, of Deer Lodge, Montana and San Antonio, TXRick Ward, of Deer Lodge, Montana and San Antonio,Texas, a pioneering prostate cancer awareness advocate and activist, died recently of chronic obstructive pulmonary disease (COPD).

Rick, an Air Force veteran aged 71, will be remembered for his tremendous contribution to Seedpods brachytherapy mailing list, for his dedication to helping Veterans faced with cancer and other health problems, for popularizing the sky blue ribbon as an emblem of prostate cancer awareness, and for advocating for equitable funding for prostate cancer research.

Rick discovered he had prostate cancer at age 56 in September 1994 in Deer Lodge, Montana when a PSA test at a free screening clinic during Prostate Cancer Awareness Week came back at a high 14 ng/mL. He called the National Cancer Institute at 1-800-4CANCER; and as an early internet user, he joined one of the start-up online mailing lists. Continue reading Rick Ward: Pioneer Prostate Cancer Activist

VA Hospital Botches Prostate Treatments, Report

Today’s New York Times reports:  “A unit in Philadelphia operating with virtually no outside scrutiny botched 92 of 116 prostate cancer treatments over a span of more than six years.” Dr. Gary D. Kao, according to the report, ran a “rogue” cancer unit which covered up botched procedures in which radioactive “seeds” intended for the cancerous prostate landed in the bladder or near the rectum. Dr. Kao’s team rewrote treatment plans, according to the Times, to cover up his bad aim. Continue reading VA Hospital Botches Prostate Treatments, Report