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New Pathway to Potential Therapies for Advanced Prostate Cancer

» 27 July 2011 » In Castration Resistant, Clinical trials, Hormone refractory, Metastatic, Prostate Cancer » Comments Off

Dr. Nima Sharifi

Dr. Nima Sharifi

PSA Rising /DALLAS/ – July 25, 2011 – UT Southwestern Medical Center researchers have narrowed the potential drug targets for advanced prostate cancer by demonstrating that late-stage tumors are driven by a different hormonal pathway than previously was thought.

“We have recently discovered that castration resistant prostate cancer (CRPC) is unexpectedly driven by dihydrotestosterone synthesis from adrenal precursors in a pathway that circumvents testosterone,” says Dr. Nima Sharifi, assistant professor of internal medicine and senior author of a  study in Proceedings of the National Academy of Sciences.

“The dominant pathway to DHT synthesis from adrenal precursors in CRPC [castration resistant prostate cancer] follows an alternative route that bypasses T and requires steroid 5α-reductase isoenzyme-1 (SRD5A1),” Dr. Sharifi writes.

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Provenge Trial Ongoing & Recruiting At Eight US Centers

» 25 November 2009 » In Clinical trials, Dendreon, Prostate Cancer, Provenge, Vaccines » Comments Off

An open-label study of Sipuleucel-T (Provenge) is ongoing at 8 centers across the USA. This is a Phase 2 Study enrolling men with Metastatic Castrate Resistant Prostate Cancer (CRPC).

The aim of this study is to measure the immune responses to treatment with sipuleucel-T (Provenge). All participants will receive the drug.

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Rick Ward: Pioneer Prostate Cancer Activist

» 23 September 2009 » In Brachytherapy, Early detection, Obits, Obituaries, Prostate Cancer, VA » Comments Off

Rick Ward, Prostate Cancer Awareness advocate, of Deer Lodge, Montana and San Antonio, TXRick Ward, of Deer Lodge, Montana and San Antonio,Texas, a pioneering prostate cancer awareness advocate and activist, died recently of chronic obstructive pulmonary disease (COPD).

Rick, an Air Force veteran aged 71, will be remembered for his tremendous contribution to Seedpods brachytherapy mailing list, for his dedication to helping Veterans faced with cancer and other health problems, for popularizing the sky blue ribbon as an emblem of prostate cancer awareness, and for advocating for equitable funding for prostate cancer research.

Rick discovered he had prostate cancer at age 56 in September 1994 in Deer Lodge, Montana when a PSA test at a free screening clinic during Prostate Cancer Awareness Week came back at a high 14 ng/mL. He called the National Cancer Institute at 1-800-4CANCER; and as an early internet user, he joined one of the start-up online mailing lists.

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VA Hospital Botches Prostate Treatments, Report

» 21 June 2009 » In Brachytherapy, Clinical trials, Medical error, PCa Treatments, Prostate Cancer, VA » Comments Off

Today’s New York Times reports:  “A unit in Philadelphia operating with virtually no outside scrutiny botched 92 of 116 prostate cancer treatments over a span of more than six years.” Dr. Gary D. Kao, according to the report, ran a “rogue” cancer unit which covered up botched procedures in which radioactive “seeds” intended for the cancerous prostate landed in the bladder or near the rectum. Dr. Kao’s team rewrote treatment plans, according to the Times, to cover up his bad aim.

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More on Movember – Oz & Elsewhere

» 27 December 2008 » In Awareness Events, Prostate Cancer » Comments Off

Just 11 months till next Movember! To get in the spirit, check out this Australian video, which explains, the aim of Movember is change the face of men’s health.

Movember in Grandforks, North Dakota, raised $7,000 for prostate cancer research. The money went to the Prostate Cancer Foundation in Santa Monica, Calif.

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Music Therapy Helps Relieve Anxiety of Cancer

» 19 December 2008 » In Cancer, Cancer Treatments, Complementary + Alt Med, Complementary integrative, QOL » Comments Off

Music “has Charms to sooth a savage Breast,” wrote playwright William Congreve, “To soften Rocks, or bend a knotted Oak.” But can it soothe those mired in the grief, confusion and pain of cancer diagnosis and treatment?

Music therapist Megan Gunnell at the University of Michigan Comprehensive Cancer Center thinks so. She uses music to help heal cancer patients’ spirits as well as their bodies.

UM Music therapist Megan Gunnell

UM Music therapist Megan Gunnell

listen to music downloadYou can listen to one of her music therapy sessions. You’ll need QuickTime music player . If you don’t already have it installed on your computer, you can download it for Windows or Mac in a free version from Apple.

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“Mission Healthy Men”

» 13 December 2008 » In Awareness Events, Early detection, Prevention, Prostate Cancer » Comments Off

Mission Healthy Men is a campaign in Austria to motivate men to become as health-conscious as women and to get health check-ups, especially for prostate cancer.

Under the slogan “Prevention is the future” the campaign is fundraising among banks, corporations, drug companies and orchestral concert-goers, while aiming to impact health choices by regular guys who get their autos serviced at regular intervals — or did before the recession — yet ignore their own health.

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Prostate Cancer Awareness Race Helps Men Get Healthier

» 06 December 2008 » In Advocacy, Awareness Events, Prostate Cancer » Comments Off

Charlottesville VA Prostate Cancer Awareness Race
Hundreds of men hit the ground running today in Charlottesville, VA to help find a cure for prostate cancer. And according to local NBC-29 news station, some of those men are much healthier for participating.

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Rates of prostate and other major cancers have begun to fall

» 02 December 2008 » In Cancer, Diagnosis, Prevention, Prostate Cancer, Statistics » Comments Off

Deaths and diagnoses for prostate and several other cancers fell between 2001 to 2005, the latest years for which data have been analyzed, according to reports this week by the National Cancer Institute and American Cancer Society.

Although overall cancer death rates dropped for the past 10 years, NCI says, this is the first time cancer incidence (the rate at which new cancers are diagnosed) has dropped along with overall death rates from cancers in men and women in most racial and ethnic groups.

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Penile Rehabilitation and Impotency Videos

» 25 November 2008 » In ED, Erectile dysfunction, Impotence, intimacy, Penile rehab, Prostate Cancer, QOL, Surgery » Comments Off

Chicago urologist Gerald Chodak MD has launched an innovative doctor-to-patient series of videos. “This is an evidence-based site,” Dr. Chodak says, “aimed at providing free information in an easier format than the usual sites that require reading. Over 60 videos are now completed on every aspect of this disease.”

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