Comments for PSA Rising Prostate Cancer Blog http://www.psa-rising.com/blog Sun, 24 Jul 2011 02:15:46 +0000 hourly 1 http://wordpress.org/?v=3.2.1 Comment on High-Dose IV Vitamin C Selectively Kills Cancer Cells by admin http://www.psa-rising.com/blog/2005/09/high-dose-iv-vitamin-c-selectively-kills-cancer-cells/comment-page-1/#comment-733 admin Sun, 24 Jul 2011 02:15:46 +0000 http://psa-rising.com/blog/index.php/2005/09/13/high-dose-iv-vitamin-c-selectively-kills-cancer-cells/#comment-733 Lawrence, you can search clinicaltrials.gov for ongoing trials. I 'm not aware of individual doctors who are treating prostate cancer patients with intravenous high dose vitamin C (ascorbic acid). News reports indicate that various alt med practitioners may be doing so. The cost may be exorbitant. The IV treatment may have side effects. We still have no clear evidence that IV vitamin C works against prostate (or other) cancer. Lawrence, you can search clinicaltrials.gov for ongoing trials. I ‘m not aware of individual doctors who are treating prostate cancer patients with intravenous high dose vitamin C (ascorbic acid). News reports indicate that various alt med practitioners may be doing so. The cost may be exorbitant. The IV treatment may have side effects. We still have no clear evidence that IV vitamin C works against prostate (or other) cancer.

]]> Comment on High-Dose IV Vitamin C Selectively Kills Cancer Cells by Lawrence http://www.psa-rising.com/blog/2005/09/high-dose-iv-vitamin-c-selectively-kills-cancer-cells/comment-page-1/#comment-731 Lawrence Sat, 23 Jul 2011 00:09:02 +0000 http://psa-rising.com/blog/index.php/2005/09/13/high-dose-iv-vitamin-c-selectively-kills-cancer-cells/#comment-731 Where can one fine doctors or centers which are treating prostate cancer with axcorbate IV therapy--in trials or otherwise? Where can one fine doctors or centers which are treating prostate cancer with axcorbate IV therapy–in trials or otherwise?

]]> Comment on Bisphosphonate Side Effects and a New Clinical Trial by admin http://www.psa-rising.com/blog/2009/01/bisphosphonates/comment-page-1/#comment-517 admin Tue, 30 Nov 2010 18:06:46 +0000 http://www.psa-rising.com/blog/?p=890#comment-517 Basing your conclusion on one house-guest is unwise. And bear in mind we are especially concerned here with effects on men with prostate cancer or anyone with cancer. Studies of osteonecrosis of the jaw (ONJ) and bisphosphonates typically measure correlated factors including smoking and alcohol abuse. Conclusions distinguish between causes and variables. This is not to say that ONJ is never associated with certain types of tobacco use (and alcolohol abuse). But evidence so far indictaes a real connection between ONJ and bisphosphonate use. To avoid this patients without cancer are being advised by some dentists to come off bisphosphonates every 3 years. For a recent finding of a connection between ONJ and bisphosphonates in cancer patients--a study which found no link with smoking-- see: J Clin Oncol. 2009 Nov 10;27(32):5356-62. Epub 2009 Oct 5. Longitudinal cohort study of risk factors in cancer patients of bisphosphonate-related osteonecrosis of the jaw. http://www.ncbi.nlm.nih.gov/pubmed/19805682 621 patients who received 29,006 intravenous doses of BP, given monthly. Crude ONJ incidence was 8.5%, 3.1%, and 4.9% in patients with multiple myeloma, breast cancer, and prostate cancer, respectively. Patients with breast cancer demonstrated a reduced risk for ONJ development, which turned out to be nonsignificant after adjustment for other variables. Multivariate analysis demonstrated that use of dentures (aOR = 2.02; 95% CI, 1.03 to 3.96), history of dental extraction (aOR = 32.97; 95% CI, 18.02 to 60.31), having ever received zoledronate (aOR = 28.09; 95% CI, 5.74 to 137.43), and each zoledronate dose (aOR = 2.02; 95% CI, 1.15 to 3.56) were associated with increased risk for ONJ development. Smoking, periodontitis, and root canal treatment did not increase risk for ONJ in patients receiving BP. Basing your conclusion on one house-guest is unwise. And bear in mind we are especially concerned here with effects on men with prostate cancer or anyone with cancer. Studies of osteonecrosis of the jaw (ONJ) and bisphosphonates typically measure correlated factors including smoking and alcohol abuse. Conclusions distinguish between causes and variables. This is not to say that ONJ is never associated with certain types of tobacco use (and alcolohol abuse). But evidence so far indictaes a real connection between ONJ and bisphosphonate use. To avoid this patients without cancer are being advised by some dentists to come off bisphosphonates every 3 years.

For a recent finding of a connection between ONJ and bisphosphonates in cancer patients–a study which found no link with smoking– see:
J Clin Oncol. 2009 Nov 10;27(32):5356-62. Epub 2009 Oct 5.
Longitudinal cohort study of risk factors in cancer patients of bisphosphonate-related osteonecrosis of the jaw.
http://www.ncbi.nlm.nih.gov/pubmed/19805682

621 patients who received 29,006 intravenous doses of BP, given monthly. Crude ONJ incidence was 8.5%, 3.1%, and 4.9% in patients with multiple myeloma, breast cancer, and prostate cancer, respectively. Patients with breast cancer demonstrated a reduced risk for ONJ development, which turned out to be nonsignificant after adjustment for other variables. Multivariate analysis demonstrated that use of dentures (aOR = 2.02; 95% CI, 1.03 to 3.96), history of dental extraction (aOR = 32.97; 95% CI, 18.02 to 60.31), having ever received zoledronate (aOR = 28.09; 95% CI, 5.74 to 137.43), and each zoledronate dose (aOR = 2.02; 95% CI, 1.15 to 3.56) were associated with increased risk for ONJ development. Smoking, periodontitis, and root canal treatment did not increase risk for ONJ in patients receiving BP.

]]> Comment on Bisphosphonate Side Effects and a New Clinical Trial by Ozijim http://www.psa-rising.com/blog/2009/01/bisphosphonates/comment-page-1/#comment-512 Ozijim Mon, 22 Nov 2010 11:35:16 +0000 http://www.psa-rising.com/blog/?p=890#comment-512 Have a house guest who claims jaw necrosis. Heavy smoker! On checking that out, smoking looks like a risk factor up there with the intravenous dose regime for bisphosphonates. Strange that esophageal cancer is also a product of smoking. Perhaps there is a simpler explanation for these cases than the coincidental use of bisphosphonates. How many of the 23 cases were neither active smokers nor passive smokers? Have a house guest who claims jaw necrosis. Heavy smoker! On checking that out, smoking looks like a risk factor up there with the intravenous dose regime for bisphosphonates. Strange that esophageal cancer is also a product of smoking. Perhaps there is a simpler explanation for these cases than the coincidental use of bisphosphonates. How many of the 23 cases were neither active smokers nor passive smokers?

]]> Comment on Viral Message — Ayurvedic Treatment for H1N1/Swine Flu by Naturesformulary http://www.psa-rising.com/blog/2009/10/viral-message-ayurvedic-med-for-h1ni-flu/comment-page-1/#comment-379 Naturesformulary Wed, 16 Dec 2009 14:06:46 +0000 http://www.psa-rising.com/blog/?p=2160#comment-379 <a href="http://www.naturesformulary.com/" rel="nofollow">Ayurvedic Medicine</a> is valuable to people of all ages because of the holistic nature and philosophy of treating the root cause of symptoms. It is sensible to perform some research and choose a therapist who is either a member of, or accredited by, an association or professional body. Ayurvedic practitioners are constrained to a code of ethics and process that finds out the therapy is carried out in a appropriate and safe environment. Ayurvedic Medicine is valuable to people of all ages because of the holistic nature and philosophy of treating the root cause of symptoms. It is sensible to perform some research and choose a therapist who is either a member of, or accredited by, an association or professional body. Ayurvedic practitioners are constrained to a code of ethics and process that finds out the therapy is carried out in a appropriate and safe environment.

]]> Comment on Free Yoga Classes for Cancer Survivors: by MashaC http://www.psa-rising.com/blog/2009/04/free-yoga-classes-for-cancer-survivors/comment-page-1/#comment-325 MashaC Mon, 16 Nov 2009 06:45:41 +0000 http://www.psa-rising.com/blog/?p=947#comment-325 Yoga Bear is a terrific organization, that just had an amazing fund raiser in Santa Monica, CA. You can read more about the event for Yoga Bear and see photos of the benefit at the My Teen Topix blog. http://www.myteentopix.com/2009/11/phenomenal-yoga-bear-benefit-raises.html Yoga Bear is a terrific organization, that just had an amazing fund raiser in Santa Monica, CA. You can read more about the event for Yoga Bear and see photos of the benefit at the My Teen Topix blog. http://www.myteentopix.com/2009/11/phenomenal-yoga-bear-benefit-raises.html

]]> Comment on ASTRO Prostate Cancer News Headlines Preview by maack1 http://www.psa-rising.com/blog/2009/10/astro-prostate-cancer-preview/comment-page-1/#comment-304 maack1 Sat, 31 Oct 2009 20:28:00 +0000 http://www.psa-rising.com/blog/?p=2199#comment-304 Keep us posted as the conference continues. Keep us posted as the conference continues.

]]> Comment on Rick Ward: Pioneer Prostate Cancer Activist by arb5643 http://www.psa-rising.com/blog/2009/09/rick-ward-pioneer-pca-activist/comment-page-1/#comment-291 arb5643 Fri, 25 Sep 2009 12:09:13 +0000 http://www.psa-rising.com/blog/?p=2008#comment-291 When my husband was diagnosed in 1997, I was the one who did all of the research regarding PCa and treatment. Rick was a great help and support to me. He even sent me a small golden walnut which was the symbol of PCa at the time. Although we didn't correspond frequently in the ensuing years, we stayed in touch on a sporadic basis. It was good to have him in my corner when I needed him. When my husband was diagnosed in 1997, I was the one who did all of the research regarding PCa and treatment. Rick was a great help and support to me. He even sent me a small golden walnut which was the symbol of PCa at the time. Although we didn’t correspond frequently in the ensuing years, we stayed in touch on a sporadic basis. It was good to have him in my corner when I needed him.

]]> Comment on Rick Ward: Pioneer Prostate Cancer Activist by dthatch87 http://www.psa-rising.com/blog/2009/09/rick-ward-pioneer-pca-activist/comment-page-1/#comment-290 dthatch87 Thu, 24 Sep 2009 23:32:08 +0000 http://www.psa-rising.com/blog/?p=2008#comment-290 Shortly after my seeding Oct. '02, my wife and I planned a "romantic getaway" to celebrate the end of my treatment. As the date approached I sent an email to the Seedpods list wondering how long the ED effects of hormone ablation lasted and should we postpone our getaway until I was functional again. I received a wonderful response from Rick Ward both chastising me for equating romance with sex only and then pointing out all the romantic alternatives to sex to make a memorable weekend. He was right, of course, and I'll always remember that weekend and Rick's email. I'm sure Rick touched many lives in addition to mine and we were all blessed to have him. Thank you Rick. May you rest in peace. Shortly after my seeding Oct. ’02, my wife and I planned a “romantic getaway” to celebrate the end of my treatment. As the date approached I sent an email to the Seedpods list wondering how long the ED effects of hormone ablation lasted and should we postpone our getaway until I was functional again. I received a wonderful response from Rick Ward both chastising me for equating romance with sex only and then pointing out all the romantic alternatives to sex to make a memorable weekend. He was right, of course, and I’ll always remember that weekend and Rick’s email. I’m sure Rick touched many lives in addition to mine and we were all blessed to have him. Thank you Rick. May you rest in peace.

]]> Comment on Fosamax Linked to Esophageal Cancer by Herb S http://www.psa-rising.com/blog/2008/12/fosamax-linked-to-esophageal-cancer/comment-page-1/#comment-87 Herb S Thu, 01 Jan 2009 23:30:28 +0000 http://www.psa-rising.com/blog/?p=879#comment-87 I would like to suggest an alternative for men (and women) to consider instead of bisphosphonates: Strontium. In the mid 1980s, a Prof. Skornya investigated the use of strontium (Sr) salts for protection of bone density. At that time, BMD testing was not as easy as it is today, but his results did indicate benefits. I am not referring to radioactive strontium 89 used to treat bone mets (but don't forget this sentence), nor am I referring to the radioactive Sr 90 formed during early atomic bomb detonations and ultimately found in milk. I am talking about plain ole Strontium 88, which is very similar to Calcium and, not surprisingly, also ends up in bones. One paragraph in the Skornya paper intrigued me: He tried to assess whether strontium (88) salts also had an effect on bone mets but was unable to draw any conclusion. Fast forward to the current decade. A compound called strontium ranelate is being extensively studied in Europe and is reported to have significant bone density and fracture protection benefits in postmenopausal women. Side effects seem to be very limited. It has one other advantage: it was patentable while other strontium salts are "public domain". Papers on strontium ranelate again suggest that strontium affects osteoclasts (bone removal) and osteoblasts (bone building) in a [beneficial] manner similar to bisphosphonates (and Vitamin K2 - see LEF 01/09, p65). When strontium 89 chloride is used for bone metastases (for pain control, I believe), it is also believed to become part of the bone at the met sites. Putting these ideas together, I decided to try readily available strontium citrate (over the counter!) for bone density--with the remote hope that it might also prevent bone mets. It appears to have worked for my bone density. At this point, without known bone mets, I can't say if it has done anything in that area. Few doctors know anything about strontium, even for bone density; their knowledge is limited to awareness of strontium 89 for pain alleviation. Dr. Strum and a few others are now mentioning otc, non-radioactive strontium salts as alternatives for bone density . I am not recommending this; I am only suggesting you might want to investigate strontium. And, because the data are so limited, I would love to hear anything new you might uncover. I would like to suggest an alternative for men (and women) to consider instead of bisphosphonates: Strontium.

In the mid 1980s, a Prof. Skornya investigated the use of strontium (Sr) salts for protection of bone density. At that time, BMD testing was not as easy as it is today, but his results did indicate benefits.

I am not referring to radioactive strontium 89 used to treat bone mets (but don’t forget this sentence), nor am I referring to the radioactive Sr 90 formed during early atomic bomb detonations and ultimately found in milk. I am talking about plain ole Strontium 88, which is very similar to Calcium and, not surprisingly, also ends up in bones. One paragraph in the Skornya paper intrigued me: He tried to assess whether strontium (88) salts also had an effect on bone mets but was unable to draw any conclusion.

Fast forward to the current decade. A compound called strontium ranelate is being extensively studied in Europe and is reported to have significant bone density and fracture protection benefits in postmenopausal women. Side effects seem to be very limited. It has one other advantage: it was patentable while other strontium salts are “public domain”.

Papers on strontium ranelate again suggest that strontium affects osteoclasts (bone removal) and osteoblasts (bone building) in a [beneficial] manner similar to bisphosphonates (and Vitamin K2 – see LEF 01/09, p65). When strontium 89 chloride is used for bone metastases (for pain control, I believe), it is also believed to become part of the bone at the met sites.

Putting these ideas together, I decided to try readily available strontium citrate (over the counter!) for bone density–with the remote hope that it might also prevent bone mets. It appears to have worked for my bone density. At this point, without known bone mets, I can’t say if it has done anything in that area.

Few doctors know anything about strontium, even for bone density; their knowledge is limited to awareness of strontium 89 for pain alleviation. Dr. Strum and a few others are now mentioning otc, non-radioactive strontium salts as alternatives for bone density .

I am not recommending this; I am only suggesting you might want to investigate strontium. And, because the data are so limited, I would love to hear anything new you might uncover.

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