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Some cancer cells feed on glutamine, study finds

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Last Updated (Tuesday, 24 January 2012 00:28) Written by Administrator Wednesday, 11 January 2012 01:14

If cancer cells are starved for glucose and oxygen they can convert glutamine into glutathione to obtain energy, a study by Johns Hopkins researchers finds.

Cancer cells have been long known to have a “sweet tooth,” using vast amounts of glucose for energy and for building blocks for cell replication.

Now, this study, by a team of researchers at Johns Hopkins and elsewhere, shows that lymph gland cancer cells called B cells can use glutamine in the absence of glucose for cell replication and survival, particularly under low-oxygen conditions, which are common in tumors.

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First Evidence of Virus Link to Some Prostate Cancers

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Cancer Viruses

Sunday, 06 September 2009 19:00

A type of virus known to cause leukemia and sarcomas in animals has been found for the first time in human prostate cancer cells, according to researchers at the University of Utah and Columbia University medical schools. Their discovery may help in identifying a viral cause of prostate cancer.This would open opportunities for developing diagnostic tests, vaccines, and therapies for treating the cancer.

The researchers say they found the XMRV virus in almost a third of the prostate tumors they looked at.

"We found that XMRV was present in 27 percent of prostate cancers we examined and that it was associated with more aggressive tumors," said Ila R. Singh, M.D., Ph.D., associate professor of pathology at University of Utah and the study’s senior author. "We still don’t know that this virus causes cancer in people, but that is an important question we’re going to investigate."

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Cancer Vaccine Plus Interleukin-7 Boosts Immune Response to Cancer

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Vaccines

Sunday, 26 April 2009 08:00

Scientists have discovered that combining interleukin-7 (IL-7) – a key component of the immune system – with a viral vaccine improves the ability of the immune system to attack tumors. A Canadian team at The Campbell Family Institute for Breast Cancer Research (CFIBCR) at Princess Margaret Hospital, Toronto say their discovery could be included in new clinical trials that use a patient’s own cells to destroy tumors.

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New Method of Teaching Immune System to Recognize A Prostate Cancer Marker, PSMA

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Vaccines

Last Updated (Monday, 27 April 2009 22:38) Sunday, 19 April 2009 21:26

PSMA (prostate specific membrane antigen) is a marker expressed in advanced prostate cancer in many men including men with bone metastases. Several methods of exploiting it to target cells and prostate  tumors are in clinical trials or under research. Prostate cancer patients in an ongoing Phase 1 study have been treated with designer T cells modified by retroviral gene therapy.

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Autopsy Study Links Prostate Cancer to Single Rogue Cell

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Last Updated (Monday, 27 April 2009 22:58) Thursday, 16 April 2009 16:08

BALTIMORE, April 16. One single cell -- a cell altered by one initial set of genetic changes -- is all it takes to begin a series of events that lead to metastatic cancer. Now, Johns Hopkins experts have tracked how the cancer process began in 33 men with prostate cancer who died of the disease. Culling information from autopsies, their study points to a set of genetic defects in a single cell that are different for each person's cancer.

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