New Pathway to Potential Therapies for Advanced Prostate Cancer

27 July 2011 Filed under Castration Resistant, Clinical trials, Hormone refractory, Metastatic, Prostate Cancer Posted by » Comments Off

Dr. Nima Sharifi

Dr. Nima Sharifi

PSA Rising /DALLAS/ – July 25, 2011 – UT Southwestern Medical Center researchers have narrowed the potential drug targets for advanced prostate cancer by demonstrating that late-stage tumors are driven by a different hormonal pathway than previously was thought.

“We have recently discovered that castration resistant prostate cancer (CRPC) is unexpectedly driven by dihydrotestosterone synthesis from adrenal precursors in a pathway that circumvents testosterone,” says Dr. Nima Sharifi, assistant professor of internal medicine and senior author of a  study in Proceedings of the National Academy of Sciences.

“The dominant pathway to DHT synthesis from adrenal precursors in CRPC [castration resistant prostate cancer] follows an alternative route that bypasses T and requires steroid 5α-reductase isoenzyme-1 (SRD5A1),” Dr. Sharifi writes.

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Provenge available for men with advanced prostate cancer at Roswell Park

15 February 2011 Filed under Hormone refractory, Immunotherapy, Metastatic, PCa Treatments, Prostate Cancer, Provenge, Vaccines Posted by » Comments Off

February 7 2011, BUFFALO, NY — The nation’s first FDA-approved cancer treatment vaccine, Provenge (sipuleucel-T), is being offered for the first time in Western New York at Roswell Park Cancer Institute (RPCI). The vaccine is designed for men with advanced prostate cancer who have limited treatment options and who meet eligibility requirements.

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How does a robotic prostatectomy work?

15 February 2011 Filed under Laparoscopic surgery, Prostate Cancer, Radical Prostatectomy, Robotic surgery Posted by » Comments Off

Robot assisted prostate surgery, known medically as the da Vinci prostatectomy, has had a profound influence over treatment during the past decade. Robotic surgical technology was first developed by the military for use in the battlefield. However during the past decade, this technology has been rapidly applied to the general medical setting, notably in the field of prostate cancer.

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Dendreon Sets Provenge Price at $93,000 – Only 2,000 Patients Will Get it in First Year

29 April 2010 Filed under Dendreon, Prostate Cancer, Provenge, Vaccines Posted by » Comments Off

Dendreon is pricing Provenge high and for the first year its availability will be low, according to a report today in Xconomy, a Seattle business website. Provenge, the first immunotherapy to win FDA approval for treatment of men with prostate cancer, will cost $93,000 per patient. Only 2,000 patients will be treated with Provenge in the first year.

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FDA Approves PROVENGE ® for the Treatment of Men with Advanced Prostate Cancer

29 April 2010 Filed under Cancer, FDA, Prostate Cancer, Provenge, Vaccines Posted by » Comments Off

SEATTLE, April 29, 2010 –Dendreon Corporation (Nasdaq: DNDN) today announced that the U.S. Food and Drug Administration (FDA) has approved PROVENGE(®) (sipuleucel-T), an autologous cellular immunotherapy for the treatment of asymptomatic or minimally symptomatic metastatic, castrate-resistant (hormone-refractory) prostate cancer (CRPC). Provenge is designed to induce an immune response against Prostatic Acid Phosphatase (PAP), an antigen expressed in most prostate cancers, and is the first in a new therapeutic class known as autologous cellular immunotherapies.

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U.S. cancer trials near state of crisis, report

16 April 2010 Filed under Cancer, Cancer research, clinical trials conduct of Posted by » Comments Off

The U.S. government’s cancer research network is in severe disarray according to a report by the Institute of Medicine. Waste and inefficiency cause 40% of all late-stage government funded cancer trials to be abandoned before completion, the report found. Shannon Pettypiece at Bloomberg.com and Liz Jones at FierceBiotech say the report paints a doomladen picture.

“The system used to conduct cancer clinical trials in the U.S. is ‘approaching a state of crisis,’ with waste and inefficiency creating difficulties for those wanting to undertake these studies,” Jones writes.

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Phase 3 Trial Underway for MDV 3100 for Advanced Prostate Cancer

15 April 2010 Filed under Cancer, Clinical trials, MDV 3100, Metastatic, Prostate Cancer, trial results Posted by » Comments Off

In light of favorable results from the Phase 1-2 trial of MDV 3100 for advanced prostate cancer, a Phase 3 trial is enrolling at sites in the US, Canada, South America, UK, Europe, Australia, and South Africa. Results from the earlier trial are published online by the UK medical journal The Lancet.

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Provenge Trial Ongoing & Recruiting At Eight US Centers

25 November 2009 Filed under Clinical trials, Dendreon, Prostate Cancer, Provenge, Vaccines Posted by » Comments Off

An open-label study of Sipuleucel-T (Provenge) is ongoing at 8 centers across the USA. This is a Phase 2 Study enrolling men with Metastatic Castrate Resistant Prostate Cancer (CRPC).

The aim of this study is to measure the immune responses to treatment with sipuleucel-T (Provenge). All participants will receive the drug.

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A Mural for a Cancer Patient Tells a Story of Broken Healthcare

09 November 2009 Filed under Awareness Events, Cancer, Healthcare Reform Posted by » Comments Off

Regina Holliday prepares her supplies for a day of painting. Photo by Maggie Starbard, NPR.

Regina Holliday prepares her supplies for a day of painting. Photo by Maggie Starbard, NPR.

Regina Holliday has painted a mural on the side of a gas station in Washington DC to tell the story of a day in her husband Fred’s struggle with broken healthcare. At ge 39, Fred was diagnosed with stage IV kidney cancer.

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Obesity as a Factor in Prostate Cancer Treatment Options

06 November 2009 Filed under PCa Treatments, Prostate Cancer, Robotic surgery Posted by » Comments Off

BY DOUGLAS SCHERR M.D.

Dr. Douglas Scherr, MD

Dr. Douglas Scherr, MD

Obesity is becoming an increasing concern with regard to prostate cancer treatment decisions as the number of patients with a Body Mass Index (BMI) of greater than 30 grows. While there hasn’t been conclusive study into the area, it has been generally found that obesity is a negative risk factor for prostate cancer.

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