James Watson, the scientist who was one of the discoverers of the double-helical structure of DNA, says in an op-ed today that the National Cancer Institute (NCI) is “a largely rudderless ship in dire need of a bold captain.” Aside from that, Watson is optimistic:

Kurt Donsbach, 73, who markets supplements including some for conditions of the prostate, was arrested April 8 during his internet radio show “Let’s Talk Health” on a warrant charging him with 11 felonies including treating patients without a license, misbranding drugs for sale, grand theft, unlawfully dispensing drugs as a cure for cancer and falsely representing a cure for cancer. Bail was set at $1,500,000.

A San Diego news site reports: “District Attorney Bonnie Dumanis said that Kurt Walter Donsbach, 73, “preyed on vulnerable patients who were looking for medical help.”

Arraigned April 13, Donsbach plead not guilty in San Diego’s downtown Superior Court. Bail was lowered to $250,00.

On December 24, 2008 the US Food & Drug Administration granted tentative approval to Accord Healthcare’s bicalutamide.

Accord is a subsidiary of Intas Pharmaceuticals, Ltd., an Indian company. Accord’s function is licensing and marketing.

In submitting Provenge vaccine for the treatment of advanced prostate cancer for fast-tracked FDA approval despite aborting one clinical trial due to failure to meet the primary endpoint, Dendreon relied on meta-analysis of combined data from two parts of a phase III study, D9901. In fact, after the trials failed to meet their primary endpoint, time to progression, they were analysed twice over. Dr. Eric Small presented meta-analyses of impact on overall survival and prostate cancer specific survival and Dr. Daniel Petrylak presented a further analysis or suvival focused on a subset of patients who, when they progressed on Provenge, took Taxotere.